Recent Publications (Link to PubMed)


Hara, M., Petrova, B., and Orr-Weaver, T. L. (2017)
Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. eLife, 6, e22219  

Alexander, J.L., Beagan, K, Orr-Weaver, T.L. and McVey, M (2016)
Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells. PNAS vol. 113  no. 48, 13809-13814

Eichhorn SW, Subtelny AO, Kronja I, Kwasnieski JC, Orr-Weaver TL, Bartel DP. (2016)
mRNA Poly(A)-tail Changes Specified by Deadenylation Broadly Reshape Translation in Drosophila Oocytes and Early Embryos. Elife. 5, e16955.

Nordman J.T., Orr-Weaver T.L. (2015)
Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein. Bioessays. 37, 856-61.

Alexander J.L., Barrasa M.I., Orr-Weaver T.L. (2015)
Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair. Curr Biol. 25, 1654-60

Orr-Weaver T.L. (2015)
When bigger is better: the role of polyploidy in organogenesis. Trends Genet. 31, 307-15

Hua B.L., Li S., Orr-Weaver T.L. (2014)
The role of transcription in the activation of a Drosophila amplification origin. G3 (Bethesda). 4 , 2403-8

Kronja I., Whitfield Z.J., Yuan B., Dzeyk K., Kirkpatrick J., Krijgsveld J., Orr-Weaver T.L. (2014)
Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Proc. Natl. Acad. Sci. U S A. 111 , 16023-8

Nordman J.T., Kozhevnikova E.N., Verrijzer C.P., Pindyurin A.V., Andreyeva E.N., Shloma VV., Zhimulev I.F., Orr-Weaver T.L. (2014)
DNA Copy-Number Control through Inhibition of Replication Fork Progression. Cell Rep. 9 , 841-9

Nogueira C., Kashevsky, H., Pinto B., Clarke A., Orr-Weaver T.L. (2014)
Regulation of Centromere Localization of the Drosophila Shugoshin MEI-S332 and Sister-Chromatid Cohesion in Meiosis. G3 (Bethesda). 4 , 1849-58

Kronja I., Yuan B., Eichhorn S.W., Dzeyk K., Krijgsveld J., Bartel D.P., Orr-Weaver T.L. (2014)
Widespread Changes in the Posttranscriptional Landscape at the Drosophila Oocyte-to-Embryo Transition. Cell Rep. 7, 1495-508.

Unhavaithaya, Y. and Orr-Weaver, T.L. (2013)
Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation. Proc. Natl. Acad. Sci. U S A. 110, 19878-83.

Whitfield ZJ, Chisholm J, Hawley RS, Orr-Weaver, T.L. (2013)
A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol. 11, e1001648.

Unhavaithaya Y, Park EA, Royzman I, Orr-Weaver, T.L. (2013)
Drosophila embryonic cell-cycle mutants. G3 (Bethesda). 3, 1875-80.

Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL. (2013)
Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells. Proc. Natl. Acad. Sci. U S A. 110, 9368-9373.

Unhavaithaya, Y. and Orr-Weaver, T.L. (2012)
Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. Genes and Dev. 26, 31-36.

Sher, N., Bell, G.W., Li, S., Nordman, J., Eng, T., Eaton, M.L., MacAlpine, D.M., and Orr-Weaver, T.L. (2012)
Developmental control of gene copy number by repression of replication initiation and fork progression. Genome Res. 22, 64-75.

Kim, J. C. and Orr-Weaver, T.L. (2011)
Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Proc. Natl. Acad. Sci. USA 108, 16681-16686.

Nordman, J., Li, S., Eng, T., MacAlpine, D., and Orr-Weaver, T. L.(2011)
Developmental control of the DNA replication and transcription programs. Genome Research 21, 175-181.

Kim, J. C., Nordman, J., Xie, F., Kashevsky, H., Eng, T., Li, S., MacAlpine, D.,
and Orr-Weaver, T. L.(2011)

Integrative analysis of amplification in Drosophila follicle cells: Parameters of origin activation and repression. Genes and Dev 25, 1384-1398.

Hongay, C. F. and Orr-Weaver, T.L.(2011)
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc. Natl. Acad. Sci. USA. 108,14855-14860.

Vardy, L., Pesin, J. and Orr-Weaver, T.L. (2009)
Regulation of Cyclin A protein in meiosis and early embryogenesis. Proc. Natl. Acad. Sci. USA. 106, 1838-1843.

Resnick, T.D., Dej, K.D., Xiang, Y., Hawley, R.S., Ahn, C. and Orr-Weaver, T.L. (2009)
Mutations in the chromosome passenger complex and the condensin complex differentially affect synaptonemal complex disassembly and metaphase I configuration in Drosophila female meiosis. Genetics. 181, 875-887.

Xie F, Orr-Weaver TL. (2008)
Isolation of a Drosophila amplification origin developmentally activated by transcription. Proc Natl Acad Sci U S A. Jul 15;105(28):9651-6.

Pesin JA, Orr-Weaver TL. (2007)
Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet.(11):e202.

Doroquez DB, Orr-Weaver TL and Rebay I.(2007)
Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev. 124(9-10):792-806.

Park EA, MacAlpine DM and Orr-Weaver TL. (2007)
Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. Proc Natl Acad Sci U S A. 104(43):16739-46.

Hartl T, Boswell C, Orr-Weaver TL, Bosco G. (2007)
Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 116(2):197-214.

Vardy L, Orr-Weaver TL. (2007)
The Drosophila PNG kinase complex regulates the translation of cyclin B. Dev Cell. 12(1):157-66.

Tadros W, Goldman AL, Babak T, Menzies F, Vardy L, Orr-Weaver T, Hughes TR, Westwood JT, Smibert CA, Lipshitz HD. (2007)
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by PAN GU kinase. Dev Cell. 12(1):143-55.

Recent Reviews

Hua, B.L and Orr-Weaver, T.L. (2017)
DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression. GENETICS, vol. 207  no. 1, 29-47

Alexander, JL and Orr-Weaver, TL (2016)
Replication fork instability and the consequences of fork collisions from rereplication. Genes and Dev. 30, 2241-2252

Frawley, L.E. and Orr-Weaver, T.L. (2015)
Curr Biol.25, R353-358.

Orr-Weaver, T.L. (2015)
When bigger is better: the role of polyploidy in organogenesis.
Trends Genet. 31, 307-315

Nordman, J. and Orr-Weaver, T.L. (2012)
Regulation of DNA replication in development.
Development 139, 455-464

Kronja, I. and Orr-Weaver, T. L. (2011)
Translational regulation of the cell cycle: When, where, how, and why?
Phil. Trans. R. Soc. B 366, 3638-3652.

Von Stetina J.R., Orr-Weaver T.L. (2011)
Developmental control of oocyte maturation and egg activation in metazoan models.
Cold Spring Harbor Perspectives in Biology 3, a005553.

Pesin JA, Orr-Weaver T.L.(2008)
Regulation of APC/C Activators in Mitosis and Meiosis. Annu Rev Cell Dev Biol. 24: 475-499

Vardy L, Orr-Weaver TL.(2007)
Regulating translation of maternal messages: multiple repression mechanisms. Trends Cell Biol. 17(11):547-54.